Changes around Withington Library will see the junction from Wellington Road to Wilmslow Road shut off with Rippingham Road made one way travelling westbound.
Davenport Avenue will also be made one way towards the busy commuter route of Wilmslow Road to “deter non-local traffic”, councillor planners have said.
New trees and paving will be put in place in the newly expanded area of public space.
Meanwhile, a section of Copson Street between Wilmslow Road and Patten Street will be partly pedestrianised with new trees, lights and seats added.
The route will be made one way from west to east, with access limited to blue badge holders, waste, emergency and loading vehicles, as well as office employees.
It comes after 72 per cent of people who took part in a consultation backed changes to the areas to make them more attractive, a council spokeswoman said.
