A woman has been arrested on suspicion of causing serious injury by dangerous driving after two pedestrians were left with life-threatening injuries.
The incident happened in Manchester city centre at about 22:30 BST on Saturday, police said.
The 30-year-old Toyota Yaris driver was travelling down Whitworth Street West, coming off Deansgate, when she lost control of her car, colliding with a Vauxhall Corsa before mounting the kerb and hitting a Kia Sportage.
Two pedestrians, an 18-year-old man and an 18-year-old woman, were also struck and both remain in hospital.
