Sawhney has worked with artists including Paul McCartney, Sting, Annie Lennox, releasing more than 20 albums across a genre-defying career.
The Rochester-born musician’s collaboration with the Hallé will take place at the Bridgewater Hall on 5 December.
He said the orchestra was “one of his favourites”, and he was looking forward to performing the original composition with them.
He said: “I am musically focusing on what happened around me at the time in relation to how I was medically treated.
“But also the aftermath of it in relation to my mental and emotional state.”