United host Greek champions PAOK on Thursday, looking for their first win in this season’s Europa League.
Leny Yoro, a £52m signing from Lille last summer, participated in full training on Wednesday after fracturing his foot in August.
The Frenchman is yet to make his competitive debut for the club.
“He’s been managed very well after his injury in pre-season, obviously we knew it was going to be a long one,” said Van Nistelrooy.
“It’s a big moment for him as it’s the first time that he’s been back in full training.
“We will bring him back partially over the coming weeks and look to get him on board as soon as possible.”
Midfielders Christian Eriksen, Mason Mount and Antony were also in training following recent absences.
