Passengers were pictured on the tracks earlier after being asked to leave the station when a small section of the tram came off.
Those affected have been told tickets will be accepted on commercial bus services, and apologised to those whose journey’s have been disrupted.
The derailment means there are currently no trams running between the Deansgate Castlefield stop and those in Old Trafford, Firswood, MediaCity and Wharfside.
A Metrolink spokesman said staff were “currently working hard to resolve this issue as soon as possible”.