AA president Edmund King said drivers can expect the closure to have “a significant impact” on journeys.
The motoring organisation’s advise to drivers was to give the M25 in Surrey a “wide berth”.
Steve Gooding, director of motoring research charity the RAC Foundation, said: “For drivers who’ve already had their patience tried by the queues at the junction 10 works, the phrase ‘you ain’t seen nothing yet’ springs to mind.”
The closure will be the first of five between now and September as part of a £317m upgrade project.
